Ruxolitinib Controls Lymphoproliferation and Diabetes in a STAT3-GOF Patient
نویسندگان
چکیده
منابع مشابه
Pulmonary cryptococcosis in a ruxolitinib-treated patient with primary myelofibrosis
We present the case of a 79-year-old man who showed multiple pulmonary nodules on chest computed tomography (CT) after being treated for 6 months with ruxolitinib, an inhibitor of Janus kinase (JAK) 1 and 2, to treat primary myelofibrosis. We examined the lesions by bronchoscopy, and the biopsy specimen revealed fungus bodies of Cryptococcus with granulomatous inflammation. As a result, the pat...
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The signal transducer and activator of transcription (STAT) family of transcription factors orchestrate hematopoietic cell differentiation. Recently, mutations in STAT1, STAT5B, and STAT3 have been linked to development of immunodysregulation polyendocrinopathy enteropathy X-linked-like syndrome. Here, we immunologically characterized 3 patients with de novo activating mutations in the DNA bind...
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Background & Objectives: CVA (cerebrovascular accident) is the most common debilitating disease. Studies show that magnesium and potassium have significant neuroprotective effects. The aim of this study is evaluation of serum levels of potassium and magnesium in stroke patients. Materials & Methods: In this case study, 70 stroke patients were entered in following manner. For a patient, a questi...
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Germline loss-of-function mutations in the transcription factor signal transducer and activator of transcription 3 (STAT3) cause immunodeficiency, whereas somatic gain-of-function mutations in STAT3 are associated with large granular lymphocytic leukemic, myelodysplastic syndrome, and aplastic anemia. Recently, germline mutations in STAT3 have also been associated with autoimmune disease. Here,...
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this study intends to investigate samuel beckett’s waiting for godot and endgame under the lacanian psychoanalysis. it begins by explaining the most important concepts of lacanian psychoanalysis. the beckettian characters are studied regarding their state of unconscious, and not the state of consciousness as is common in most beckett studies. according to lacan, language plays the sole role in ...
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ژورنال
عنوان ژورنال: Journal of Clinical Immunology
سال: 2020
ISSN: 0271-9142,1573-2592
DOI: 10.1007/s10875-020-00864-w